
A research powerhouse with an unusually structured venture programme through the Polsky Center and Booth's New Venture Challenge.
The University of Chicago is known for rigorous economics, physical sciences, and its business school, Booth. It manages Argonne and Fermi national laboratories, giving it access to research infrastructure few universities can match.
That combination produces founders at both ends: quantitative finance and enterprise software on one side, deep physical science on the other.
The Polsky Center for Entrepreneurship and Innovation coordinates venture activity, and Booth's New Venture Challenge is one of the longest-running and most successful university startup competitions in the country.
Duality, a quantum-focused accelerator run with Argonne, reflects the university's unusual access to national laboratory research.
Grubhub emerged from the New Venture Challenge, co-founded by a Chicago Booth student. The university's broader output spans fintech and trading technology, enterprise software, and increasingly quantum and materials science ventures from its national laboratory connections.
Chicago's investor base includes Hyde Park Venture Partners, Chicago Ventures, and Pritzker Group Venture Capital, alongside the trading and quantitative finance community that provides both capital and technical talent.
Northwestern · Michigan · MIT
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